You have a couple of options for how to spend your hard-won Crystals. One of them is definitely not worth your time, however.
Bless Unleashed Soul Crystals | How to get Soul Crystals
Bless Unleashed rewards you with Soul Crystals for defeating Unique Bosses. You can only take on these field bosses with other players, and each region has just one Unique Boss. However, Adventure Dungeons have three Unique Bosses to challenge. Whatever your method of choice, the boss’ HP will scale depending on how many people are in your party, so keep that in mind.
Bless Unleashed Soul Crystals | What to do with Soul Crystals
Soul Crystals have just one use: exchanging with the Monster Hunter NPC in various towns. He offers several special goods for Soul Crystals, but you want to be careful what you get. The Monster Hunter NPC gives you a choice of boss boxes or skins for Soul Crystals. Don’t buy the boxes — or if you do, make sure it’s one of the higher level ones.
The boxes he sells are the same ones you get for defeating the eponymous bosses, e.g., the Bone Dragon box is what you also receive for defeating the Bone Dragon. The difference is you get the boss drops for free. The items inside are random and frequently disappointing, but getting low-level gear from a random drop is much less annoying than spending items to get disappointing equipment. Unless you just have a surplus of crystals and want to spend them, we recommend saving them for the Monster Hunter’s unique cosmetic items and skins instead. If you’re looking for a different kind of fantasy MMO experience, we’ve got the Destiny 2 guides to help get you started on a sci-fi adventure, including how to get some of the newest weapons and free cosmetics each month.